Adverse drug events (ADEs) are a major cause of morbidity in the primary care setting.
+1 Patients with medical conditions that require multiple medications experience more ADEs and drug-related morbidity and mortality than patients taking fewer medications.
+2,+3 More than 50% of hospital admissions secondary to medication-associated problems are potentially preventable.
+4 Treatment of HIV infection is generally associated with a large pill burden as a result of combination medication regimen use for highly active antiretroviral therapy.
+5,+6